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Whole heart radiomics were better than the clinical variables for differentiating subjects with different Agatston scores (≤400 and 40 (area under the curve [AUC] 0.92 vs 0.69). Prediction of coronary stenosis and MESA 10-Y CHD risk was better on whole heart radiomics (AUC0.86-0.87) than with clinical variables (AUC0.69-0.79). Addition of clinical variables or visual assessment of coronary calcification from LDCT to whole heart radiomics resulted in a modest change in the AUC. Single-click, whole heart radiomics obtained from LDC
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