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OBJECTIVE Persons with Huntington's disease (HD) often have communication difficulties and cognitive impairments, making mental health assessment difficult. Informants close to the patient are often included in assessments. The authors investigated effects of informant presence during assessment of persons with HD. METHODS Data for four subsamples from ENROLL-HD were examined manifest for HD (N=4,109), premanifest (N=1,79, genotype negative (N=1,041), and family members with no genetic risk (N=974). Assessment interviews with and witho
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