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Kind we collagen fibers and macrophage flooded within the entire SMMC7721 tumefaction xenografts. Tumor angiogenesis was of good heterogeneity through the periphery into the center area. But, the receptor-binding web site obstacles were supposed to be the best cause of bad penetration of GE11-TLs. We anticipate these images can give a deep reconsideration for rational design of target nanoparticles for beating biological barriers to drug delivery. © 2020 Chinese Pharmaceutical A