https://www.selleckchem.com/pr....oducts/z-vad(oh)-fmk
Epigenetic dysfunction is implicated in many neurologic, psychiatric and oncologic diseases. Consequently, histone deacetylases (HDACs) inhibitors have been developed as therapeutic and imaging agents for these diseases. However, only a few radiotracers have been developed as HDACs imaging agents for the central nervous system (CNS). We report herein the synthesis and evaluation of [ F]INER-1577-3 ([ F]5) as an HDACs imaging agent for CNS. [ F]INER-1577-3 ([ F]5) was synthesized by two methods one-step (A) and two-step ( methods
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