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88; 95% confidence interval 1.79-9.12; p less then 0.001). The number of drugs used also positively influenced the occurrence of hemolysis (p less then 0.001). No patient presented evidence of molecular resistance to rifampicin, dapsone, or ofloxacin treatment, as evidenced by genetic sequencing detection of rpoB, folp1, and gyrA mutations. Conclusions Polypharmacy has deleterious effects on the already difficult-to-adhere-to treatment of leprosy and polypharmacy induces hemolysis. Additional measures must be taken to avoid the undesirab
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