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94, 95% CI-1.48,-0.40, p=0.001). Additionally, there was considerable effect on TAC level by using≥20mg/d melatonin and in people under 35 years old. MDA level also decreased using dosage of below 20mg/d and in people≥35 years old. The present study showed a promising effect of melatonin administration for reducing MDA, PCO, and increasing TAC levels. However, further studies especially with more attention to PCO level assessment are needed to confirm the findings of the present study in larger samples on different populations. The prese