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The analysis unveils that the physicochemical heterogeneity produced by the AuNPs on the PDMS area could guide the hole-formation, influence the common spacing involving the holes formed at the initial dewetting stage, and impacts the spacing and periodicity of this droplets formed at the end of the dewetting stage. The scale and spacing of this holes additionally the droplets might be tuned by different the nanoparticle loading on the PDMS substrate. Inter