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Our results suggest that the TDI may be considered a highly sensitive biomechanical index, reflecting the overall motor condition in PD, and provided of clinical relevance due to the correlation with the clinical evaluation.The oxygen and hydrogen isotopic compositions (δ18O and δ2H) were measured on river water and precipitation collected from four sub-catchments within the upper Tuojiang River catchment. δ18O values of river water and precipitation exhibit significant seasonal variations. These seasonal variations are used for estimatin