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In conclusion, our study suggests that targeting PAI-1 and interfering with its upstream regulators may benefit breast cancer patients.Local warming induced by rapid urbanization has been threatening residents' health, raising significant concerns among urban planners. Local climate zone (LCZ), a widely accepted approach to reclassify the urban area, which is helpful to propose planning strategies for mitigating local warming, has been well documented in recent years. Based on the LCZ framework, many scholars have carried out diversifi