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Further, the in vivo experiments showed that PG reduced both tumor growth and invasion in the xenograft OS mice model. The results provide valuable insight into the possible underlying mechanisms of PG effects in the human osteosarcoma cells which could be used as a potential anticancer drug for OS treatment.Migraine has a very high lifetime prevalence with a severe illness-related burden. As a result, extensive long-term and regular treatment is required, which cannot be covered solely by neurologists. This is particularly the case for