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82 (95% confidence interval 0.72-0.88). The cut-off values of DTF for prediction of NIV failure were 36.3% and 37.1% for the operator 1 and 2 (p 0.0001), respectively. The cut-off value of respiratory rate/DTF ratio for prediction of NIV failure was 0.6 for both operators (p 0.0001). DTF and respiratory rate/DTF ratio may both represent valid, feasible and noninvasive tools to predict NIV outcome in patients with de-novo ARF. Trial registration ClinicalTrials.gov Identifier NCT02976233, registered 26 November 2
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