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CouC4A@SiO 2 features as a reversible sensor for Fe3+ by using ATP in vitro along with biological cells. Therefore, the inorganic-organic crossbreed product, such as, CouC4A@SiO 2 , is an indispensable material for sensitive and painful and selective detection of Fe3+ in a picomolar range in solution plus in nanomolar to micromolar range in biorelevant fluids and biological cells, respectively.Stabilization for tetrylone complexes, which carry ylidone( ligands [(CO)5W-X (YCp*)2] (X =