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© 2020 Li et al.Introduction Encapsulated Streptococcus pneumoniae strains cause high morbidity and mortality, primarily in nations with no pneumococcal conjugate vaccines (PCVs) immunization system. This research investigated the epidemiological modifications of S. pneumoniae isolates including serotype distribution and antimicrobial susceptibility in Tehran, Iran. Methods A total of 80 S. pneumoniae samples had been gathered from patients admitted to Shariati medical center