https://www.selleckchem.com/pr....oducts/stat3-in-1.ht
Whole marrow RNA-seq revealed widespread transcriptional changes only in responders with baseline differences in genes involved in ribosome biogenesis, oxidative phosphorylation and metabolic pathways. This study confirmed the efficacy of panobinostat as a single agent in multiple myeloma and established acetylation of lymphocyte histones, modulation of immune subsets and transcriptional changes as pharmacodynamic biomarkers of clinical benefit.Genetic studies in patients with Philadelphia-negative myeloproliferative neoplasms (MPNs)
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