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On day 7, the straight coil was more comfortable than the curved coil with a visual analogue scale (VAS) score of 77 ± 21 compared to 94 ± 11 ( = 0.028), respectively. No other ocular adverse events were observed. Comfort and safety of the straight and curved ocular coil are high. Because the retention time is too short for long-term sustained drug release, the use in the perioperative or immediate postoperative period could prove to be more valuable. The ocular coil is a noninvasive, comfortable and safe short-term drug delivery device.