https://www.selleckchem.com/pr....oducts/pirtobrutinib
Skin pharmacokinetics is an indispensable indication for studying the drug fate after administration of transdermal drug delivery systems (TDDS). However, the heterogeneity and complex skin structured with stratum corneum, viable epidermis, dermis, and subcutaneous tissue inevitably leads the drug diffusion coefficient ( p) to vary depending on the skin depth, which seriously limits the development of TDDS pharmacokinetics in full thickness skin. A multilayer geometry skin model was established and the p of drug in SC, vi
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