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A high rate of additional laser may be needed to achieve RD prophylaxis, and higher-risk cases may be identified at presentation and referred to specialists. © 2020 S. Karger AG, Basel.INTRODUCTION Introduction of retinal gene therapy requires established outcome measures along with thorough understanding of the pathophysiology. Evidence of early, thinned outer segments in RPGR X-linked RP could help understand how the level of cone photoreceptor involvement translates to visual potential. OBJECTIVE Analysis of foveal photoreceptor outer segment l