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003, OR=6.011, 95% Cl 1.852-19.512). The pre-operative pancreatic stent substantially reduced the incidence of CR-POPF in patients with tumor located in proximity to (distance ≤2mm) the MPD (CR-POPF of the stented group vs the non-stented group 37.5% vs 71.4%, p=0.028). The distance from insulinoma to MPD ≤2mm is a predictive factor for CR-POPF after enucleation. Pancreatic duct stenting may benefit patients with insulinoma in proximity to the MPD by enabling a lower CR-POPF rate, so it should be considered before the enucleation of the