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First Line Treatment For ADHD in Adults Some people with ADHD are able to use medications to manage their symptoms. The stimulants, like methylphenidate and amphetamine, are effective in boosting activity in brain areas that control attention and behavior. Other medications, like the non-stimulant drug atomoxetine and certain antidepressants perform differently, but they are effective. Patients taking medications should consult their GP regularly to observe bodily reactions and alter