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Further, this analysis shows that the skin explant test is a viable alternative to animal testing for complex mixtures or commercially available products. In this study, we aimed to retrospectively evaluate the volumes and cosmetic scores of mixed-type and spongy-type thyroid nodules treated with ethanol and radiofrequency (RF) ablation before and after treatment. In addition, the safety and efficacy of ethanol and RF ablation treatment methods were compared. In the radiology department, mixed-type and spongy-type benign thyroid nodules un