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71%). The methodology proposed in this study is simple, robust, and cost-effective and can be used to provide additional insights into the operation of an anaerobic digester such as assessing the mixing efficiency.The development of computer aid models for heavy metals (HMs) simulation has been remarkably advanced over the past two decades. Several machine learning (ML) models have been developed for modeling HMs over the past two decades with outstanding progress. Although there have been a noticeable number of diverse ML models investigations, it is essen