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© the writers; licensee ecancermedicalscience.Background  Interstitial cystitis (IC) or bladder pain syndrome (BPS) is very painful and disabling and probably the most misdiagnosed urologic condition. Its classic the signs of perineal discomfort, urinary urgency, and regularity despite sterile urine countries were currently explained a lot more than a century ago in a study on soldiers during World War (WW) I as a result of chronic pudenda