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To evaluate the antifungal efficiency of various intracanal medicaments against . One-hundred and forty extracted human mandibular premolar teeth were decoronated, and the biomechanical preparation was done in crown-down technique. 10 μL culture suspension of was placed into the prepared root canal space of all the teeth. After 21 days of incubation, all the teeth were randomly divided into 7 groups with 20 teeth per each group. Group I triple antibiotic powder (TAP) mixed with 3% chitosan solution; group II TAP mixed with macrogol-prop