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This study aimed to gauge the end result of RA on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in zebrafish embryos. Embryos were challenged with MPTP and then were treated with RA or brusatol (a Nrf2 inhibitor). Locomotor activity of zebrafish was recorded using a video camera. The swimming distance had been reviewed with SMART 3.0 pc software. Tyrosine hydroxylase (TH) immunohistochemistry, reactive oxygen species (RO