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e., as volume reduction increases, high pressures appear in other parts of the socket which generate discomfort. Therefore, a trade-off is required between the amount of rectification and the balance of the pressure distributions experienced at the stump.There is a clinical need to identify children with poor asthma control as early as possible, to optimize treatment and/or to find therapeutic alternatives. Here, we present the "Systems Pharmacology Approach to Uncontrolled Pediatric Asthma" (SysPharmPediA) study, which aims to establish a
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