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We envisage that our results will introduce a toolbox for designing efficient untethered soft robots for fluidic environments. Copyright © 2020 the Author(s). Published by PNAS.Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system. Dysregulation of STAT3, a transcription factor pivotal to various cellular processes including Th17 cell differentiation, has been implicated in MS. Here, we report that STAT3 is activated in infiltrating monocytic cells near active MS lesions and that activation of STAT3 in mye