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Adult ADHD and Comorbid Disorders Many people with ADHD have comorbid disorders such as major depression (Kessler et al 2006). Many patients who are depressed are not able to respond well to medications and may get better results from therapy. Medications that most effectively improve the symptoms of ADHD appear to increase and regulate levels of certain neurotransmitters in the brain. Commonly prescribed stimulants include amphetamine, methylphenidate, and similar medications. Medicines Adults ar