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There have been 12 NDAs pre-2009 (32 trials, N = 11,567) and 3 NDAs post-2009 (14 trials, N = 6,434). INFORMATION EXTRACTION Baseline demographic and condition varirent worldwide nature of drug development, close awareness of test conduct and reexamination of design elements for future trials can be warranted. © Copyright 2020 Physicians Postgraduate Press, Inc.Prion real time quaking-induced conversion (RT-QuIC) is an ultrasensi