https://www.selleckchem.com/btk.html
This study developed a nanocrystals-in-microparticles (NCs/MPs) technology for improving dissolution and oral absorption of poorly soluble drugs. Hydroxycamptothecin (HCPT) was selected as a model drug and prepared to be nanocrystals (HCPT-NCs) by acid-alkali based precipitation. The HCPT-NCs were rod like shape with the length of 250 nm and the width of 50 nm. Then, the chitosan and sodium alginate were selected as microparticles matrix to encapsulate the HCPT-NCs. The HCPT-NCs were entrapped in microparticles with a D50 value of 15 µm. The drug lo
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