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Treatment For ADHD Psychosocial therapy is the main treatment for add. The medications contain stimulants such as methylphenidate amphetamine, and atomoxetine. They also include non-stimulants, such as clonidine and guanfacine. Stimulant medication should not be used by patients who have active substance abuse issues, however they can be considered in those who are in stable recovery. Combination treatment with antidepressants (particularly SSRIs) is also an option. Stimulants Stimulant