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Adult ADHD and Comorbid Disorders Many adults suffering from ADHD also suffer from comorbid conditions such as major depressive disorder (Kessler and colleagues 2006). Many patients who are depressed aren't able to take medication and could benefit from therapy. Medications that most effectively improve the symptoms of ADHD appear to increase and balance levels of specific brain chemicals called neurotransmitters. The most commonly prescribed stimulants are methylphenidate, amphetamine and other similar dru