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Fibronectin, that is an adhesive and regulatory necessary protein regarding the intercellular matrix, can act as one of several markers of these procedures. The purpose of the investigation was to study the result of a high-fructose diet on rat serum fibronectin amount. Material and methods. The experiment ended up being performed on 50 outbred male rats aged 5-6 months. Rats through the control group (n=25) received a well-balanced diet of vivarium. Pets regarding the experim