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Health Issues That Affect German Shepherd Life Expectancy German Shepherds are at their peak between 2 and 6 years old. They're at their strongest in terms of physical fitness and mental sharpness. They are at a higher risk for illnesses of the musculoskeletal system and other health conditions which can affect their lifespan. German Shepherds in the working line typically lead more active lives than their show line counterparts. They require a nutrient-rich diet to help them meet their active lifestyle and demands for exercise. Cushing's Disease