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We tested the hypothesis that differences in ventilatory ([Formula see text]) or convection requirement ([Formula see text]/[Formula see text]O2) response to hypoxia would be correlated with differences in hemoglobin (Hb) oxygen affinity between two strains of rats, as they have been shown to be among several species of mammals, birds and reptiles. Brown Norway (BN) rats reduce metabolism more than they increase ventilation in response to hypoxia and both the ventilatory and convection requirement responses to hypoxia are lower in the
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