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eeded to better understand the physiological basis for these effects. This NMA showed that, to reduce genital infection risk, current evidence favors DPP4 inhibitors over SGLT2 inhibitors. Most SGLT2 inhibitors may not be associated with the risk of urinary tract infections. Considering both infection risks, saxagliptin may be the safest drug. Finally, mechanistic studies are needed to better understand the physiological basis for these effects.Multiple myeloma (MM) is still extremely difficult to cure, and new therapeutic drugs are nee