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is indicative of a detrimental response in primary cultured astrocytes experiencing iron and extracellular α-syn. Copyright © 2020 Cui, Guo, Li, Song and Xie.Aggregation of α-Synuclein, possibly caused by disturbance of proteostasis, has been identified as a common pathological feature of Parkinson's disease (PD). However, the initiating events of aggregation have not been fully illustrated, and this knowledge may be critical to understanding the disease mechanisms of PD. Proteostasis is essential in maintaining normal cellular metaboli