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First Line Treatment For ADHD in Adults Some people with ADHD discover that medication can help to manage their symptoms. Stimulants, like amphetamine and methylphenidate, are effective in boosting activity in the brain regions that regulate attention and behavior. Other medications, like the nonstimulant atomoxetine as well as some antidepressants, function differently, but are also effective. People taking medication should see their GP regularly to observe the effects on the body and alter dosages.