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Treatment For ADHD The most effective treatment options for add are medications and psychosocial therapy (psychotherapy). include stimulants such as methylphenidate, amphetamine, and atomoxetine. They may also be non-stimulants, such as clonidine and guanfacine. The use of stimulants should not be used by patients who have active addiction issues, but they are an option for those who are in stable remission. Combination therapy with antidepressants (particularly SSRIs) is also an option. Stimulants S