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ADHD Treatment For Adults Stimulants like methylphenidate, amphetamine and other brain chemicals can increase levels. Non-stimulants such as atomoxetine and antidepressants perform slower than stimulants but they may be as effective. Comorbid conditions can alter the effectiveness of ADHD medication. Physicians should address the most severe symptoms of any co-occurring disorder first, and then check to see if the ADHD symptoms improve. Medication The most commonly