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Alongside an aging population, osteoporosis has become increasingly common, representing a major public health problem. Human blood provides the predominant matrix for pathological targets underlining disease mechanisms. In the present study, the protein profiles of blood plasma exosomes from patients with osteoporosis, osteopenia, and those with normal bone mass were compared. The aim of the study was to search for potential novel diagnostic/therapeutic targets for further investigation in osteoporosis. A total of 60 participants were i