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Sepsis is a life-threatening disease caused by the dysregulated host response to the infection, and being the major cause of death to patients in intensive care unit (ICU). Early diagnosis of sepsis could significantly reduce in-hospital mortality. Though generated from infection, the development of sepsis follows its own psychological process and disciplines, alters with gender, health status and other factors. Hence, the analysis of mass data by bioinformatic tools and machine learning is a promising method for exploring early diagno