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To determine the variations in the lasting medical effects between Regeneration (REG) and conventional procedure (CS) in infra-bony defects. Three databases had been searched [PubMed, Medline and Embase] up to April 2019. Following evaluating, 17 scientific studies were included. Randomized Controlled Clinical Trials, Controlled Clinical Trials and retrospective scientific studies with long-lasting clinical observations (≥ 24-months) had been selected. After subg