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Therefore, further attention in the future on potential technologies, namely explosive decompression, microfluidization, pulsed arc technology, is required to supplement the discussed techniques. This article summarizes recent advances in cell disruption methods and demonstrates insights on new directions of the techniques and future developments.Hyperuricemia (HUA) is a metabolic disorder caused by abnormal uric acid (UA) metabolism, which is a complex physiological process involving multiple organs (liver, kidney, and intestine). Alth