https://www.selleckchem.com/pr....oducts/Odanacatib-(M
Whilst the survival rates of childhood acute lymphoblastic leukemia (ALL) have increased remarkably over the last decades, the therapy resistance and toxicity are still the major causes of treatment failure. It was shown that overexpression of heme oxygenase-1 (HO-1) promotes proliferation and chemoresistance of cancer cells. In humans, the HO-1 gene (HMOX1) expression is modulated by two polymorphisms in the promoter region (GT)n-length polymorphism and single-nucleotide polymorphism (SNP) A(-413)T, with short GT repeat seq
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