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001), and LS was associated with the QOL. Furthermore, the results indicated that LS and QOL in patients with HIV/AIDS were at low levels.Naegleria species (spp.) is a free-living amoebae whose pathogenic species such as N. fowleri pose a significant health risk to young people and the most important source of infection is water source. This study aims to perform a systematic review and meta-analysis of the data on the prevalence of Naegleria spp. in water sources of the available literature. Included articles on the prevalence of Naeg