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with high blood pressure, especially in countries with a high risk of stroke. Our pooled result showed that nearly one-fifth of stroke patients have died during hospitalization. The most common risk factor of stroke among the included studies was hypertension followed by atrial fibrillation and diabetes mellitus. There is a need for a better understanding of the factors associated with high blood pressure, especially in countries with a high risk of stroke. Interleukin 36 (IL-36), as a gradually recognized cytokine, is involved in the occurrence and evoluti