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1 levels in a small proportion of CTCL patients do not support an essential role for IL31 in CTCL patients. Translational and transcriptional expression levels of IL31 were very low or undetectable in CTCL patients. Detectable low IL31 serum levels were exclusively observed in SS and FMF patients and not in patients with classic MF. However, these marginal IL31 levels in a small proportion of CTCL patients do not support an essential role for IL31 in CTCL patients. Immortalized mammalian cell lines are a valuable research tool, though the