https://www.selleckchem.com/pr....oducts/apx-115-free-
The knockdown of DRAM1 could alleviate colitis symptoms in mice. In in vitro experiments, knocking down DRAM1 could reduce autophagy and apoptosis levels. Mechanistically, DRAM1 may participate in the regulation of these two processes by positively regulating JNK activation. During intestinal inflammation, the upregulation of DRAM1 may promote the activation of JNK and further aggravate intestinal epithelium damage. During intestinal inflammation, the upregulation of DRAM1 may promote the activation of JNK and further aggravat
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