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https://www.selleckchem.com/pr....oducts/doxycycline.h
As results, the first or seventh amino acid of the HI2 peptide was replaced with Arg, Trp, or Tyr. We found that all 30 HI2 peptides had significantly higher activity than the original sequence (100%) and 26 of the 30 HI3 peptides were significantly active (86.7%). However, the actual inhibitory activity of the HI3 peptides was improved to a lesser extent. The docking simulation clarified that the CDOCKER energy decrease was roughly correlated with the inhibitory activity. The machine learning-based predictive model was a promising