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First Line Treatment For ADHD in Adults Some people with ADHD are able to use medications to manage their symptoms. Drugs like methylphenidate and amphetamine help by enhancing brain activity in the areas that regulate attention and behavior. Other medications, like the non-stimulant drug atomoxetine and certain antidepressants perform differently, yet are effective. Regular visits to the GP is recommended for patients who take medication. They can adjust dosages and check for the body's reactio